Analytical Data
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Gene name
TRIP13
- Application
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Alternative Names
TRIP13；PCH2；Pachytene checkpoint Protein 2 homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15645
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Expression Region
1-432aa
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AA Sequence
MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLAAYI
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Molecular Weight
54.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIP13 (Thyroid hormone receptor interactor 13) is a member of the AAA+ ATPase family and plays a crucial role in various cellular processes, particularly in the regulation of cell cycle and DNA repair mechanisms. Research has increasingly focused on TRIP13 due to its involvement in mitosis and meiosis, where it functions to promote the disassembly of protein complexes that restrain the activation of essential biological pathways. Its activity is particularly significant in facilitating the progression of cancer, as aberrations in TRIP13 expression have been linked to tumorigenesis and poor prognosis across multiple cancer types. Additionally, TRIP13 has been implicated in the modulation of the spindle assembly checkpoint, ensuring accurate chromosome segregation during cell division. Recent studies have also explored its potential as a therapeutic target, as inhibiting its function may enhance the effectiveness of existing cancer treatments. The understanding of TRIP13’s structure and mechanism of action continues to deepen, paving the way for innovative approaches in cancer therapy, as researchers seek to unravel the complexities of its role in both normal cell function and pathological conditions.
