Analytical Data
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基因名
TRIP13
- Application
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别名
TRIP13；PCH2；Pachytene checkpoint Protein 2 homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15645
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表达区间
1-432aa
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氨基酸序列
MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTEFDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENIIAANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDKQFEERKKLAAYI
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分子量
54.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIP13 (Thyroid hormone receptor interactor 13) is a member of the AAA+ ATPase family and plays a crucial role in various cellular processes, particularly in the regulation of cell cycle and DNA repair mechanisms. Research has increasingly focused on TRIP13 due to its involvement in mitosis and meiosis, where it functions to promote the disassembly of protein complexes that restrain the activation of essential biological pathways. Its activity is particularly significant in facilitating the progression of cancer, as aberrations in TRIP13 expression have been linked to tumorigenesis and poor prognosis across multiple cancer types. Additionally, TRIP13 has been implicated in the modulation of the spindle assembly checkpoint, ensuring accurate chromosome segregation during cell division. Recent studies have also explored its potential as a therapeutic target, as inhibiting its function may enhance the effectiveness of existing cancer treatments. The understanding of TRIP13’s structure and mechanism of action continues to deepen, paving the way for innovative approaches in cancer therapy, as researchers seek to unravel the complexities of its role in both normal cell function and pathological conditions.
