Analytical Data
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基因名
MAGOH
- Application
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别名
MAGOH;MAGOHA;Protein mago nashi homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61326
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表达区间
1-146aa
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氨基酸序列
MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
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分子量
44.2kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAGOH is a crucial component of the exon junction complex (EJC), which plays a significant role in mRNA processing, surveillance, and translation. This protein has gained attention in recent years due to its involvement in cellular processes such as gene expression regulation and RNA transport. Research into MAGOH's structure and function has been spurred by its association with various diseases, including cancer and neurodegenerative disorders, where its dysregulation may contribute to disease progression. Particularly, MAGOH has been implicated in the modulation of alternative splicing and nonsense-mediated mRNA decay, which are vital for maintaining cellular homeostasis and response to stress. Scientists aim to explore MAGOH's potential as a therapeutic target, leveraging its pivotal role in post-transcriptional regulation. Understanding its biochemical pathways and interactions with other EJC components may shed light on its contribution to cellular functions and highlight strategies for intervention in diseases where MAGOH expression is altered. This research is crucial not only for fundamental biology but also for developing novel therapeutic approaches that harness the regulatory capabilities of MAGOH and its associated pathways.
