Analytical Data
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Gene name
LDLRAP1
- Application
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Alternative Names
LDLRAP1;ARH;Low density lipoProtein receptor adapter Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5SW96
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Expression Region
1-308aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MDALKSAGRA LIRSPSLAKQ SWGGGGRHRK LPENWTDTRE TLLEGMLFSL KYLGMTLVEQ PKGEELSAAA IKRIVATAKA SGKKLQKVTL KVSPRGIILT DNLTNQLIEN VSIYRISYCT ADKMHDKVFA YIAQSQHNQS LECHAFLCTK RKMAQAVTLT VAQAFKVAFE FWQVSKEEKE KRDKASQEGG DVLGARQDCT PPLKSLVATG NLLDLEETAK APLSTVSANT TNMDEVPRPQ ALSGSSVVWE LDDGLDEAFS RLAQSRTNPQ VLDTGLTAQD MHYAQCLSPV DWDKPDSSGT EQDDLFSF
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LDLRAP1, or Low-Density Lipoprotein Receptor Adaptor Protein 1, is a critical component in the pathway of lipoprotein metabolism and cellular cholesterol homeostasis. Research into LDLRAP1 has gained prominence due to its pivotal role in mediating the endocytic trafficking of LDL receptors, which are essential for the uptake of low-density lipoproteins (LDL) from the bloodstream. Mutations in the LDLRAP1 gene have been linked to familial hypercholesterolemia, a genetic disorder characterized by elevated cholesterol levels and an increased risk of cardiovascular diseases. The understanding of LDLRAP1's function is further enhanced by studies indicating its involvement in other cellular processes, such as lipid metabolism and insulin signaling. Consequently, LDLRAP1 has emerged as a potential therapeutic target for conditions associated with dyslipidemia. By exploring the properties of recombinant LDLRAP1 proteins, researchers aim to elucidate the molecular mechanisms underlying its functions and the broader implications for cholesterol metabolism and cardiovascular health. This research not only contributes to the foundational knowledge in lipid biology but also holds promise for developing novel interventions to manage cholesterol-related disorders.
