Analytical Data
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基因名
IL11Ra
- Application
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别名
IL11Ra；Interleukin-11 receptor subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14626
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表达区间
1-422aa
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氨基酸序列
MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPG VTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGA LGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRK KTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNP LGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQP HFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSL QPHPRLLDHRDSVEQVAVLASLGTLSFLGLVAGALALGLWLRLRRGGKDG SPKPGFLASVIPVDRRPGAPNL
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分子量
72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-11 receptor (IL-11Ra) is a crucial component of the interleukin-11 signaling pathway, which plays a significant role in mediating inflammatory responses and regulating various physiological processes, including hematopoiesis and fibrosis. The study of IL-11Ra has garnered interest in the context of various diseases, particularly those associated with chronic inflammation and tissue remodeling, such as idiopathic pulmonary fibrosis, inflammatory bowel disease, and certain cancers. Research indicates that IL-11 signaling can contribute to the promotion of fibrosis and the maintenance of pathological inflammation. By understanding the structure and function of the IL-11Ra, researchers aim to develop targeted therapies that can inhibit its signaling pathway, potentially leading to new treatment strategies for diseases characterized by excessive fibrosis and inflammation. Recombinant IL-11Ra proteins are essential for these studies, allowing for the exploration of receptor interactions, the elucidation of downstream signaling mechanisms, and the screening of small molecules or antibodies that can modulate its activity. Continued exploration of IL-11Ra and its biological implications holds promise for advancing therapeutic options and improving clinical outcomes in patients suffering from fibrotic and inflammatory conditions.
