Analytical Data
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Gene name
LASP1
- Application
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Alternative Names
LASP1;MLN50;LIM and SH3 domain Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14847
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Expression Region
1-261aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSHMNPNCARCGKIVYPTEKVNCLDKFWH KACFHCETCKMTLNMKN YKGYEKKPYCNAHYPKQSFTMVADTPENLRL KQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRI KKTQDQISNIKY HEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQ QPQQQ PVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDE VSFQDGDTIVNVQQIDDGWMYGTV ERTGDTGMLPANYVEAI
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Molecular Weight
32 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LASP1 (Limestone and Spleen Protein 1) is a protein that has garnered significant interest in biomedical research due to its association with various cellular functions and diseases, particularly in cancer. It is a cytoskeletal protein that interacts with actin filaments and is involved in cellular processes such as migration, adhesion, and proliferation. High levels of LASP1 expression have been correlated with tumor progression and metastasis in several cancer types, making it a potential biomarker and therapeutic target. Researchers are particularly focused on generating recombinant LASP1 proteins to study their structural and functional properties, enabling a better understanding of how this protein contributes to disease mechanisms at the molecular level. Studies utilizing LASP1 recombinant proteins are also aiding in the identification of potential inhibitors or modulators that might interfere with its interaction in pathological contexts. The exploration of LASP1's role in cell signaling pathways further underlines its importance in cancer biology, positioning it as a candidate for future drug development strategies aimed at targeting specific cancer pathways. Through these efforts, the scientific community aims to unravel the complexities of LASP1's functionality and its impact on tumor behavior, which may lead to improved diagnostic and therapeutic approaches for cancer treatment.
