Analytical Data
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Gene name
LAP3
- Application
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Alternative Names
CASP7;MCH3;Caspase-7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28838-1
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Expression Region
1-519aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMFLLPLPAAGRVVVRRLAVRRFGSRSLSTA DMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKA GKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCR QIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGS GDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKT EVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFV GKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIG LAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHT FNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVW RMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHL DIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
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Molecular Weight
58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LAP3, or Leucine Aminopeptidase 3, is a member of the leukocyte-derived aminopeptidase family known for its role in the processing of peptides and proteins within the immune system. The study of LAP3 has gained significance due to its potential implications in various physiological and pathological processes, including immune response, inflammation, and cancer progression. Research indicates that LAP3 may influence the activity of other cytokines and contribute to the regulation of T cell responses, making it a critical factor in maintaining immune homeostasis. Furthermore, aberrant expression of LAP3 has been associated with several diseases, highlighting its potential as a biomarker for diagnosis or a target for therapeutic intervention. The recombinant expression of LAP3 allows for detailed biochemical studies and structural characterization, aiding in the understanding of its enzymatic functions and interactions at the molecular level. This can facilitate the exploration of LAP3's roles in health and disease, paving the way for novel strategies in immunotherapy and personalized medicine. As the field of proteomics expands, the characterization of LAP3 in various biological contexts will enhance our knowledge of immune regulation and the development of targeted therapies.
