Analytical Data
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Gene name
NLRP1
- Application
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Alternative Names
NLRP1；CARD7；DEFCAP；KIAA0926；NACHT. LRR and PYD domains-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96AM0
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Expression Region
1-146aa
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AA Sequence
MPLDPYHSVTWGHAQGSHHFVFGELRVRPILESLRDEPDPDPRPSREGPAGRVGALARGGPEPCDAASPPGGASCAPELARPREDKSAQQAKLEGGTRLCCRCPEESRLVPGGAVSPGDHVLEVSGTRGTCGCRPRRHAGPELAHS
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Molecular Weight
42.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NLRP1 (NOD-like receptor family pyrin domain containing 1) is a crucial component of the innate immune system, functioning as a pattern recognition receptor that detects various pathogens and stress signals. Research on NLRP1 has gained significant attention due to its pivotal role in inflammatory responses and its association with numerous autoimmune and autoinflammatory diseases, such as systemic lupus erythematosus and multiple sclerosis. The protein's capacity to form inflammasomes—multimeric protein complexes that activate caspase-1 and subsequently lead to the maturation and secretion of pro-inflammatory cytokines like IL-1β—has prompted extensive studies to elucidate its mechanistic pathways. Moreover, variations in the NLRP1 gene have been linked to increased susceptibility to certain diseases, illustrating its importance in health and disease. The development of recombinant NLRP1 proteins has enabled researchers to investigate its structure-function relationships and to explore potential therapeutic interventions targeting its pathways. By generating and characterizing these recombinant proteins, studies aim to unravel how NLRP1 modulation can influence inflammatory processes, providing insights into the development of new strategies for treating inflammatory conditions and enhancing our understanding of immune system regulation. As the field progresses, the exploration of NLRP1 and its recombinant derivatives holds promise for identifying novel therapeutic targets and improving disease outcomes in various inflammatory diseases.
