Analytical Data
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基因名
KRT16
- Application
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别名
KRT16;KRT16A;Keratin. type I cytoskeletal 16
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08779
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表达区间
1-473aa
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氨基酸序列
MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSRFSSGGACGLGGGYGGGFSSSSSFGSGFGGGYGGGLGAGFGGGLGAGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTKYEHELALRQTVEADVNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQTGGDVNVEMDAAPGVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQASGQSYSSREVFTSSSSSSSRQTRPILKEQSSSSFSQGQSS
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分子量
58.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT16, or keratin 16, is a member of the intermediate filament protein family, predominantly expressed in the skin, hair follicles, and nails. It plays a crucial role in providing structural integrity and resilience to epithelial tissues, particularly under conditions of mechanical stress and injury. Research on KRT16 has gained momentum due to its implications in various dermatological conditions, including psoriasis, palmoplantar keratoderma, and other skin disorders characterized by abnormal keratinization. The exploration of KRT16's function and regulation has been pivotal for understanding its involvement in the pathogenesis of these diseases. Furthermore, KRT16 is often studied in the context of tumor biology, as its expression levels can change in certain malignancies, thus serving as a potential biomarker. Advances in recombinant protein technology have facilitated the production of KRT16, enabling researchers to investigate its biochemical properties, interactions with other keratins, and role in cellular signaling pathways. By utilizing recombinant KRT16, scientists aim to uncover detailed mechanisms underlying its function, paving the way for novel therapeutic strategies targeting KRT16-related conditions and improving treatments for skin disorders. Overall, the study of KRT16 as a recombinant protein is vital for enhancing our understanding of skin biology and developing innovative approaches to address keratin-related pathologies.
