Analytical Data
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基因名
KIN17
- Application
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别名
KIN;BTCD;KIN17;DNA/RNA-binding Protein KIN17
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60870
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表达区间
1-393aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMGKSDFL TPKAIANRIK SKGLQKLRWY CQMCQKQCRD ENGFKCHCMS ESHQRQLLLA SENPQQFMDY FSEEFRNDFL ELLRRRFGTK RVHNNIVYNE YISHREHIHM NATQWETLTD FTKWLGREGL CKVDETPKGW YIQYIDRDPE TIRRQLELEK KKKQDLDDEE KTAKFIEEQV RRGLEGKEQE VPTFTELSRE NDEEKVTFNL SKGACSSSGA TSSKSSTLGP SALKTIGSSA SVKRKESSQS STQSKEKKKK KSALDEIMEI EEEKKRTART DYWLQPEIIV KIITKKLGEK YHKKKAIVKE VIDKYTAVVK MIDSGDKLKL DQTHLETVIP APGKRILVLN GGYRGNEGTL ESINEKTFSA TIVIETGPLK GRRVEGIQYE DISKLA
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分子量
48 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIN17 is an essential member of the KRAB-containing zinc-finger protein family and plays a significant role in various cellular processes, particularly in DNA repair and maintenance of genomic stability. Research into KIN17 has garnered attention due to its involvement in critical cellular pathways, including responses to oxidative stress and regulation of cell proliferation. Studies have shown that KIN17 protein interacts with components of the DNA repair machinery, suggesting its function in homologous recombination and nucleotide excision repair. Furthermore, alterations in KIN17 expression have been linked to the progression of several cancers, indicating its potential as a biomarker or therapeutic target. The recombinant expression of KIN17 protein allows for a deeper understanding of its structure-function relationships and interaction dynamics within the cellular context. By producing KIN17 in a recombinant format, researchers can analyze its biochemical properties, elucidate its role in DNA damage response, and assess its potential implications in cancer biology. This research is crucial for developing new strategies for cancer treatment and understanding the complex interplay between genomic integrity and cellular function. Overall, the study of recombinant KIN17 protein is pivotal in advancing our knowledge of its biological significance and therapeutic potential.
