Analytical Data
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基因名
H2-D1
- Application
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别名
H2-D1；H2BFB；HIRIP2；HIST1H2BD；Histone H2B type 1-D
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01900
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表达区间
25-311aa
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氨基酸序列
GSHSLRYFVTAVSRPGFGEPRYMEVGYVDNTEFVRFDSDAENPRYEPRARWIEQEGPEYWERETRRAKGNEQSFRVDLRTALRYYNQSAGGSHTLQWMAGCDVESDGRLLRGYWQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKEQKYTCHVEHEGLPEPLTLRWGKEEPPSSTKTNT
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分子量
39.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H2-D1, a major histocompatibility complex (MHC) class I molecule, plays a crucial role in the immune system by presenting endogenous peptides to CD8+ T cells, thereby influencing cellular immune responses. Research on H2-D1 recombinant proteins has gained significance due to their potential applications in vaccine development, immunotherapy, and the study of autoimmune diseases. Understanding the structural and functional characteristics of H2-D1 is essential for elucidating its role in antigen presentation and T cell activation. Additionally, the production of H2-D1 recombinant proteins allows for detailed investigations into peptide-MHC interactions, which are vital for designing effective therapeutic interventions. Various expression systems, such as bacteria, yeast, and mammalian cells, have been employed to generate bioactive H2-D1 proteins that facilitate the study of its properties and functionalities. Given the rising interest in personalized medicine and targeted therapies, H2-D1 recombinant proteins represent a promising area of research, potentially leading to novel strategies for treating cancers and infections by modulating immune responses. Overall, the exploration of H2-D1's structural and functional dynamics is pivotal for advancing our understanding of immune regulation and developing innovative therapeutic approaches.
