Analytical Data
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Gene name
H2-D1
- Application
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Alternative Names
H2-D1；H2BFB；HIRIP2；HIST1H2BD；Histone H2B type 1-D
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01900
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Expression Region
25-311aa
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AA Sequence
GSHSLRYFVTAVSRPGFGEPRYMEVGYVDNTEFVRFDSDAENPRYEPRARWIEQEGPEYWERETRRAKGNEQSFRVDLRTALRYYNQSAGGSHTLQWMAGCDVESDGRLLRGYWQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKEQKYTCHVEHEGLPEPLTLRWGKEEPPSSTKTNT
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Molecular Weight
39.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
H2-D1, a major histocompatibility complex (MHC) class I molecule, plays a crucial role in the immune system by presenting endogenous peptides to CD8+ T cells, thereby influencing cellular immune responses. Research on H2-D1 recombinant proteins has gained significance due to their potential applications in vaccine development, immunotherapy, and the study of autoimmune diseases. Understanding the structural and functional characteristics of H2-D1 is essential for elucidating its role in antigen presentation and T cell activation. Additionally, the production of H2-D1 recombinant proteins allows for detailed investigations into peptide-MHC interactions, which are vital for designing effective therapeutic interventions. Various expression systems, such as bacteria, yeast, and mammalian cells, have been employed to generate bioactive H2-D1 proteins that facilitate the study of its properties and functionalities. Given the rising interest in personalized medicine and targeted therapies, H2-D1 recombinant proteins represent a promising area of research, potentially leading to novel strategies for treating cancers and infections by modulating immune responses. Overall, the exploration of H2-D1's structural and functional dynamics is pivotal for advancing our understanding of immune regulation and developing innovative therapeutic approaches.
