Analytical Data
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基因名
CORIN
- Application
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别名
CORIN；CRN；TMPRSS10；Atrial natriuretic peptide-converting enzyme
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5Q5
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表达区间
1-110aa
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氨基酸序列
MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVS
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分子量
16.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CORIN is a critical protease that plays a significant role in the cleavage of atrial natriuretic peptide (ANP) precursors, which are crucial for regulating blood pressure and fluid balance. Dysregulation of CORIN has been linked to various cardiovascular diseases, including hypertension and heart failure. Research has focused on understanding the structure, function, and regulatory mechanisms of CORIN to exploit its potential as a therapeutic target. Studies have shown that genetic variations in the CORIN gene can influence its activity and are associated with the risk of cardiovascular disorders. Moreover, the development of CORIN-related diagnostic and therapeutic modalities is an emerging field, particularly in the context of precision medicine. The recombination of this protein is essential for exploring its mechanistic roles and developing potential interventions. Thus, the investigation of CORIN and its functionalities in pathophysiological contexts continues to be a significant area of research within cardiovascular biology.
