Analytical Data
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Gene name
KCNH6
- Application
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Alternative Names
KCNH6; ERG2; Potassium voltage-gated channel subfamily H member 6; Ether-a-go-go-related gene potassium channel 2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2; Voltage-gated potassium channel subunit Kv11.2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H252
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Expression Region
1-502aa
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AA Sequence
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGCE
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Molecular Weight
80.96 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KCNH6, a member of the voltage-gated K+ channel family, plays a significant role in regulating neuronal excitability and neurotransmitter release. This channel is predominantly expressed in the brain, suggesting its involvement in various neurological processes. Research into KCNH6 has gained traction due to its potential links to neurological disorders, including epilepsy and other ion channelopathies. The understanding of KCNH6 function has been furthered by studies examining its structural properties, electrophysiological characteristics, and the effects of mutations on its activity. Recent advances in recombinant protein technology have enabled the production of KCNH6 in heterologous systems, facilitating detailed functional studies. By expressing KCNH6 as a recombinant protein, researchers are able to analyze its ion conductance, pharmacological properties, and interaction with different cellular components. Such studies are crucial for elucidating the physiological role of KCNH6 and its impact on neuronal function. Additionally, advancements in cryo-electron microscopy and X-ray crystallography are paving the way for a more profound understanding of the channel's structural dynamics, which could lead to the identification of novel therapeutic targets for treating diseases associated with KCNH6 dysregulation. Overall, the study of KCNH6 recombinant protein represents an important frontier in the field of neurobiology, offering insights into both basic cellular mechanisms and potential clinical applications.
