Analytical Data
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基因名
KCNH6
- Application
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别名
KCNH6; ERG2; Potassium voltage-gated channel subfamily H member 6; Ether-a-go-go-related gene potassium channel 2; ERG-2; Eag-related protein 2; Ether-a-go-go-related protein 2; hERG-2; hERG2; Voltage-gated potassium channel subunit Kv11.2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H252
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表达区间
1-502aa
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氨基酸序列
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGCE
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分子量
80.96 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNH6, a member of the voltage-gated K+ channel family, plays a significant role in regulating neuronal excitability and neurotransmitter release. This channel is predominantly expressed in the brain, suggesting its involvement in various neurological processes. Research into KCNH6 has gained traction due to its potential links to neurological disorders, including epilepsy and other ion channelopathies. The understanding of KCNH6 function has been furthered by studies examining its structural properties, electrophysiological characteristics, and the effects of mutations on its activity. Recent advances in recombinant protein technology have enabled the production of KCNH6 in heterologous systems, facilitating detailed functional studies. By expressing KCNH6 as a recombinant protein, researchers are able to analyze its ion conductance, pharmacological properties, and interaction with different cellular components. Such studies are crucial for elucidating the physiological role of KCNH6 and its impact on neuronal function. Additionally, advancements in cryo-electron microscopy and X-ray crystallography are paving the way for a more profound understanding of the channel's structural dynamics, which could lead to the identification of novel therapeutic targets for treating diseases associated with KCNH6 dysregulation. Overall, the study of KCNH6 recombinant protein represents an important frontier in the field of neurobiology, offering insights into both basic cellular mechanisms and potential clinical applications.
