Analytical Data
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Gene name
IMP3
- Application
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Alternative Names
IMP3;C15orf12;MRPS4;U3 small nucleolar ribonucleoProtein Protein IMP3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NV31
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Expression Region
1-184aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMVRKLKF HEQKLLKQVD FLNWEVTDHN LHELRVLRRY RLQRREDYTR YNQLSRAVRE LARRLRDLPE RDQFRVRASA ALLDKLYALG LVPTRGSLEL CDFVTASSFC RRRLPTVLLK LRMAQHLQAA VAFVEQGHVR VGPDVVTDPA FLVTRSMEDF VTWVDSSKIK RHVLEYNEER DDFDLEA
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Molecular Weight
24 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IMP3, an oncofetal protein belonging to the insulin-like growth factor II mRNA-binding protein family, plays a critical role in various cellular processes, including cell proliferation, differentiation, and migration. Initially identified as a marker for embryonic development, IMP3 has gained attention for its association with several types of cancers, particularly in evaluating tumor growth and metastasis. Research has demonstrated that overexpression of IMP3 is linked to poor prognosis in various malignancies, including pancreatic, ovarian, and lung cancers. Understanding the molecular mechanisms behind IMP3's function can provide insight into its role as a potential biomarker for cancer diagnosis and prognosis, as well as a target for therapeutic intervention. Current studies focus on elucidating the pathways regulated by IMP3, including its interaction with microRNAs and mRNA stability, which may alter the expression of oncogenes and tumor suppressors. Furthermore, the generation of recombinant IMP3 proteins is essential for these studies, allowing for the exploration of its functional properties and the development of IMP3-targeted therapies. As cancer research progresses, investigations into IMP3's reprogramming capabilities and its impact on the tumor microenvironment hold promise for novel approaches in cancer treatment and management.
