Analytical Data
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基因名
IL-23
- Application
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别名
IL-23；Interleukin-23 receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPF7
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表达区间
23-328aa
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氨基酸序列
IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCSGSTS GSGKPGSGEG STKGRAVPGG SSPAWTQCQQ LSQKLCTLAW SAHPLVGHMD LREEGDEETT NDVPHIQCGD GCDPQGLRDN SQFCLQRIHQ GLIFYEKLLG SDIFTGEPSL LPDSPVGQLH ASLLGLSQLL QPEGHHWETQ QIPSLSPSQP WQRLLLRFKI LRSLQAFVAV AARVFAHGAA TLSP
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分子量
70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-23 (IL-23) is a vital cytokine that plays a significant role in immune responses, particularly in the differentiation and proliferation of T-helper 17 (Th17) cells. It is composed of two subunits, p19 and p40, and is crucial in mediating inflammatory responses and autoimmune diseases such as psoriasis, inflammatory bowel disease, and multiple sclerosis. Given its pivotal role in these disorders, IL-23 has become a target for therapeutic intervention. Researchers have been increasingly focused on the production and application of recombinant IL-23 proteins for both basic research and clinical purposes. The recombinant technology allows for the generation of large quantities of active IL-23, enabling detailed studies of its mechanisms in both normal and pathological conditions. Understanding IL-23 signaling pathways and its effects on immune cell populations is essential for developing IL-23 inhibitors as new treatments for autoimmune diseases. Furthermore, recombinant IL-23 is utilized in various experimental settings to explore its role in inflammation and to screen potential therapeutics, contributing to the overall understanding of immune regulation and offering promising avenues for novel interventions in immune-mediated conditions.
