Analytical Data
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基因名
IL2RG
- Application
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别名
IL2RG;Cytokine receptor common subunit gamma
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31785
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表达区间
23-262aa
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氨基酸序列
LNTTILTPNG NEDTTADFFL TTMPTDSLSV STLPLPEVQC FVFNVEYMNC TWNSSSEPQP TNLTLHYWYK NSDNDKVQKC SHYLFSEEIT SGCQLQKKEI HLYQTFVVQL QDPREPRRQA TQMLKLQNLV IPWAPENLTL HKLSESQLEL NWNNRFLNHC LEHLVQYRTD WDHSWTEQSV DYRHKFSLPS VDGQKRYTFR VRSRFNPLCG SAQHWSEWSH PIHWGSNTSK ENPFLFALEA HHHHHH
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分子量
29 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-2 receptor gamma (IL2RG) is a critical component of the interleukin-2 receptor complex, playing a pivotal role in the immune response by mediating signaling for various interleukins, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Mutations in the IL2RG gene are associated with X-linked severe combined immunodeficiency (X-SCID), a life-threatening condition characterized by the absence of functional T and NK cells, leading to severe immune deficiency. Studies on IL2RG recombinant proteins have gained prominence in the context of gene therapy and regenerative medicine, as they provide insights into the molecular mechanisms of immune signaling and the potential for therapeutic interventions. Research has focused on characterizing the structure and function of IL2RG, investigating its interaction with other signaling molecules, and developing strategies for its potential therapeutic replacement in genetic diseases. Understanding IL2RG's role in immune system development and function is key to devising effective treatment strategies for immunodeficiencies and may also contribute to improving cancer immunotherapy. The recombinant protein studies not only enhance our knowledge of the protein's biological activities but also facilitate the design of novel drugs that can modulate immune responses, ultimately paving the way for innovative treatments for various immunological disorders.
