Analytical Data
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基因名
KBTBD3
- Application
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别名
KBTBD3; BKLHD3; Kelch repeat and BTB domain-containing protein 3; BTB and kelch domain-containing protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NAB2
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表达区间
1-612aa
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氨基酸序列
MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFNKYRDPWFSNLCA
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分子量
93.72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KBTBD3, a member of the kelch repeat and BTB (Bric-a-brac, Tramtrack, and Broad Complex) domain-containing protein family, has gained attention in recent years due to its potential roles in various biological processes, including protein ubiquitination and cell signaling. This protein is implicated in the regulation of cellular pathways essential for maintaining homeostasis and responding to stress. Dysregulation of KBTBD3 has been associated with several pathological conditions, including cancer and neurodegenerative diseases, making it a candidate of interest for therapeutic interventions. Research has focused on elucidating the structure-function relationship of KBTBD3, as its unique domain architecture suggests a mechanism for substrate recognition and interaction with E3 ubiquitin ligases. Understanding the molecular mechanisms governed by KBTBD3 could offer insights into its role in disease mechanisms and contribute to the development of targeted treatments. Therefore, the generation of recombinant KBTBD3 protein is crucial for characterizing its functional properties and exploring its potential as a biomarker or therapeutic target in clinical research.
