Analytical Data
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Gene name
DEFB1
- Application
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Alternative Names
DEFB1；BD1；HBD1；Beta-defensin 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60022
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Expression Region
22-68aa
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AA Sequence
GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
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Molecular Weight
5.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Defensin beta 1 (DEFB1), a member of the defensin family, is an antimicrobial peptide that plays a crucial role in the innate immune response. It is predominantly expressed by epithelial cells in various tissues, including the respiratory and gastrointestinal tracts. DEFB1 exhibits broad-spectrum antimicrobial activity against bacteria, viruses, and fungi, making it vital for the host's first line of defense against infections. The study of DEFB1 has gained significant interest due to its potential therapeutic applications in treating infections and inflammatory diseases. Research has highlighted its role in modulating immune responses and promoting wound healing, while alterations in its expression levels have been associated with various health conditions, including inflammatory bowel disease and respiratory infections. Recombinant DEFB1 protein is increasingly being produced for both functional studies and potential therapeutic use, enabling a better understanding of its mechanisms of action and interactions within the immune system. Consequently, ongoing studies aim to optimize its production and explore its applications in developing novel antimicrobial agents and adjuvants for vaccines, underscoring the importance of this peptide in both innate immunity and clinical therapeutics.
