Analytical Data
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基因名
ATP4a
- Application
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别名
ATP4a；Potassium-transporting ATPase alpha chain 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20648
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表达区间
350-783aa
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氨基酸序列
TVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNL
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分子量
54.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP4a, encoded by the ATP4A gene, is a critical subunit of the H+-K+ ATPase enzyme, predominantly found in the gastric epithelium. This enzyme plays an essential role in maintaining the acidic environment of the stomach by facilitating the exchange of hydrogen ions (H+) for potassium ions (K+). Research into ATP4a has gained momentum due to its significant implications in gastrointestinal health, particularly in conditions such as gastric ulcers, gastroesophageal reflux disease, and various forms of gastric cancer. Dysregulation of ATP4a expression or function can lead to altered gastric acid secretion, contributing to these disorders. Additionally, understanding the molecular mechanisms regulating ATP4a may provide insights into the development of targeted therapies. Recent studies have also explored its potential role in the immune response and the microbiome's influence on gastric physiology. The investigation of ATP4a as a therapeutic target highlights its dual importance in both basic physiology and clinical applications, emphasizing the need for advanced research to elucidate its full spectrum of functions and regulatory pathways, paving the way for novel interventions in gastric-related diseases.
