Analytical Data
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Gene name
IL16
- Application
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Alternative Names
IL16;Pro-interleukin-16
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IUU6
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Expression Region
1-130aa
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AA Sequence
MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS
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Molecular Weight
13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-16, a cytokine known for its role in immune regulation, acts as a chemoattractant for CD4+ T cells and has been implicated in various inflammatory conditions, including asthma, rheumatoid arthritis, and HIV infection. The protein is notable for its ability to enhance T cell activation and modulate the immune response, making it a critical focus for therapeutic interventions. Research has shown that IL-16 may aid in the recruitment of T cells to sites of inflammation and could have implications for the development of autoimmune diseases. The study of recombinant IL-16 protein has gained momentum as scientists aim to explore its mechanisms of action, potential therapeutic applications, and role in disease progression. By producing recombinant IL-16, researchers can investigate its effects on T cell dynamics in vitro and in vivo, paving the way for new treatments that harness its immunomodulatory properties. Additionally, the structural characteristics and interaction sites of IL-16 present opportunities for drug design, highlighting its potential as a target for innovation in treating immune-related disorders. Overall, the ongoing exploration of IL-16 as a recombinant protein encapsulates a vast landscape of biomedical research aiming to unravel its intricate roles in health and disease.
