Analytical Data
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Gene name
KATNAL1
- Application
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Alternative Names
Katanin p60 ATPase containing subunit A like 1; Katanin p60 ATPase-containing subunit A-like 1; Katanin p60 subunit A like 1; Katanin p60 subunit A-like 1; KATL1_HUMAN; KATNAL1; MGC2599; OTTHUMP00000018194; OTTHUMP00000042415; OTTHUMP00000061637; p60 katanin like 1; p60 katanin-like 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BW62
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Expression Region
1-490aa
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AA Sequence
MNLAEICDNA KKGREYALLG NYDSSMVYYQ GVMQQIQRHC QSVRDPAIKG KWQQVRQELL EEYEQVKSIV STLESFKIDK PPDFPVSCQD EPFRDPAVWP PPVPAEHRAP PQIRRPNREV RPLRKEMAGV GARGPVGRAH PISKSEKPST SRDKDYRARG RDDKGRKNMQ DGASDGEMPK FDGAGYDKDL VEALERDIVS RNPSIHWDDI ADLEEAKKLL REAVVLPMWM PDFFKGIRRP WKGVLMVGPP GTGKTMLAKA VATECGTTFF NVSSSTLTSK YRGESEKLVR LLFEMARFYA PTTIFIDEID SICSRRGTSD EHEASRRVKS ELLIQMDGVG GALENDDPSK MVMVLAATNF PWDIDEALRR RLEKRIYIPL PTAKGRAELL KINLREVELD PDIQLEDIAE KIEGYSGADI TNVCRDASLM AMRRRINGLS PEEIRALSKE ELQMPVTKGD FELALKKIAK SVSAADLEKY EKWMVEFGSA
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Molecular Weight
55.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KATNAL1, a member of the kinesin superfamily, is an ATP-dependent motor protein primarily involved in the regulation of microtubule dynamics and cellular transport processes, particularly during mitosis and intracellular trafficking. Its unique structure comprises several functional domains, enabling it to interact with various cellular components and participate in critical biological processes. Research into KATNAL1 has gained traction due to its emerging role in cell division, neurogenesis, and potential implications in neurological disorders, including autism spectrum disorders and cognitive impairments. The study of recombinant KATNAL1 proteins allows for a deeper understanding of their functional mechanisms and interactions within the cell, facilitating the exploration of their roles in both normal physiology and pathophysiological conditions. Scientists utilize recombinant techniques to produce purified KATNAL1 proteins, enabling the investigation of their enzymatic activity, binding properties, and influence on microtubule organization in vitro. Additionally, these studies contribute to the broader understanding of kinesin motor proteins and their significance in cellular transport and disease mechanisms, highlighting KATNAL1 as a potential target for therapeutic interventions in related disorders. Overall, the research on KATNAL1 recombinant proteins is crucial for elucidating the complexities of intracellular transport and its relevance to human health and disease.
