Analytical Data
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Gene name
TNFaIP2
- Application
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Alternative Names
TNFaIP2；Tumor necrosis factor alpha-induced Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q03169
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Expression Region
1-654aa
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AA Sequence
MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG
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Molecular Weight
72.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TNFaIP2 (Tumor Necrosis Factor Alpha-Induced Protein 2) is a key regulatory protein that plays a significant role in various cellular processes, particularly in the context of inflammation and immune response. Initially identified as a gene whose expression is induced by tumor necrosis factor-alpha (TNF-α), TNFaIP2 has garnered attention for its involvement in modulating signaling pathways related to cellular survival, proliferation, and apoptosis. Research has demonstrated that TNFaIP2 acts as a negative regulator of the NF-κB signaling pathway, which is crucial for mediating inflammatory responses. Elevated levels of TNFaIP2 have been associated with several pathological conditions, including autoimmune diseases, cancer, and metabolic disorders, highlighting its potential as a therapeutic target. Additionally, studies have indicated that TNFaIP2 may interact with various cellular proteins, influencing processes such as cell adhesion and migration, which are essential in the context of tissue repair and tumor metastasis. As such, the recombinant expression of TNFaIP2 protein allows for detailed investigations into its structure-function relationships and interactions, providing insights that could lead to novel therapeutic strategies in managing inflammatory diseases and other related conditions. Understanding the role of TNFaIP2 at a molecular level is paramount for unraveling its contributions to disease mechanisms and developing targeted therapies aimed at modulating its activity for clinical benefit.
