Analytical Data
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基因名
IL10RA
- Application
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别名
IL10RA;IL10R;Interleukin-10 receptor subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13651
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表达区间
22-235aa
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氨基酸序列
HGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTN
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分子量
24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-10 receptor alpha (IL10RA) is a critical component of the interleukin-10 (IL-10) signaling pathway, which plays a significant role in regulating immune responses and maintaining immune homeostasis. IL-10 is an anti-inflammatory cytokine produced by various immune cells, and its binding to IL10RA is essential for mediating its effects on immune regulation, including the inhibition of pro-inflammatory cytokines and enhancement of regulatory T cell functions. Dysregulation of the IL-10 signaling pathway has been implicated in various inflammatory and autoimmune diseases, as well as in the progression of certain cancers. Consequently, the study of IL10RA and its recombinant protein holds significant promise for therapeutic interventions. By producing recombinant IL10RA, researchers aim to explore its functional properties, elucidate its role in immune regulation, and evaluate its potential as a therapeutic agent. Recombinant IL10RA could be utilized in preclinical and clinical studies to assess its efficacy in preventing or treating conditions characterized by excessive inflammation and autoimmunity. As such, the investigation of IL10RA not only enhances our understanding of immune mechanisms but also presents opportunities for developing novel strategies to modulate immune responses in various diseases.
