Analytical Data
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Gene name
HNRPK
- Application
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Alternative Names
HNRPK；HNRPK；Heterogeneous nuclear ribonucleoProtein K
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61978
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Expression Region
1-463aa
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AA Sequence
METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQ SKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEI LKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLL IHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPD RVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRP VGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRG GSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAID TWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAG SIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYL LQNSVKQYSGKFF
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Molecular Weight
77 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRPK (heterogeneous nuclear ribonucleoprotein K) is a multi-functional protein primarily involved in RNA processing and regulation, playing significant roles in mRNA metabolism, DNA repair, and cell signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, where it contributes to tumorigenesis and metastasis by affecting gene expression and cellular responses. The study of HNRPK has gained considerable attention due to its potential as a biomarker for disease prognosis and as a target for therapeutic interventions. Researchers have focused on the characterization of its structural properties and functional domains to elucidate its mechanisms of action. Since HNRPK interacts with multiple RNA species and proteins, understanding its interaction networks is crucial for deciphering its role in cellular processes. Recent advances in proteomics and molecular biology techniques have facilitated the exploration of HNRPK’s involvement in stress responses and its impact on cellular fate decisions. By characterizing HNRPK recombinant proteins, scientists aim to develop novel strategies for targeted therapies and to enhance our understanding of RNA biology in health and disease.
