Analytical Data
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Gene name
IFIT3
- Application
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Alternative Names
IFIT3;CIG-49;IFI60;IFIT4;Interferon-induced Protein with tetratricopeptide repeats 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14879
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Expression Region
1-490aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMSEVTKNSLEKILPQLKCHFTWNLFKE DSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQA EELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKF SNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLA IAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGE QFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYL YHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLN PLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDT AVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQ NGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSS SPRELLSNSEQLN
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Molecular Weight
58 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The IFIT3 (Interferon-Inducible Protein 3) is a member of the IFIT family of proteins that play critical roles in the innate immune response, particularly in the defense against viral infections. Emerging research highlights its significance in recognizing and binding to viral RNA, thereby inhibiting viral replication and influencing various signaling pathways associated with immune responses. The upregulation of IFIT3 in response to type I interferons underscores its importance during viral challenges, as it contributes to the establishment of an antiviral state within host cells. Investigations into the structural characteristics of IFIT3 have revealed its ability to interact with a variety of viral components, positioning it as a potential biomarker for viral infections and a candidate for therapeutic intervention. Moreover, the relevance of IFIT3 extends beyond virology; studies suggest its involvement in cancer immunity and autoimmune disorders, indicating a broader significance in health and disease. As researchers continue to explore the multifaceted roles of IFIT3 in pathogen recognition and immune modulation, recombinant IFIT3 protein is increasingly utilized in experimental settings to elucidate its mechanism of action and therapeutic potential. Understanding its function may pave the way for innovative strategies in vaccine development and antiviral therapies, particularly in the context of emerging viral pathogens.
