Analytical Data
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Gene name
PCDHgA2
- Application
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Alternative Names
PCDHgA2；Protocadherin gamma-A2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5I4
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Expression Region
1-884aa
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AA Sequence
MEQAGTRPAATEHPRLRRPMPWLLLLPLLLLLLLLLPGPAASQLRYSVPE EQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALF VNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFPR PNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPL QENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDT NDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYT SDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCK VLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKV SLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLT SLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKE NAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVE AQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPA GYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGD ESGSTFNLTVVVRDNGEPSLSASVAITVAVVDRVSKILPDTQRHVKSPRT YSEITLYLIIALSTVSFIFLLTIIILSIIKCYRYTAYGTACCGGFCGVRE RSPAELYKQANNNIDARIPHGLKVQPHFIEVRGNGSLTKTYCYKACLTAG SGSDTFMFYNTGAQTGPGPSGAQAAVTDSRNLTGQSGQNAGNLIILKNEA VSQNEVRQWSGGLLQTHAFVTHPPISCDLALLSH
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Molecular Weight
109 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PCDHgA2, a member of the protocadherin gene family, is a type of calcium-dependent cell adhesion protein that plays a crucial role in the development and maintenance of neuronal circuits. This protein is predominantly expressed in the brain and is believed to contribute to synaptic specificity and neuronal connectivity, making it essential for proper neural function. Research has shown that alterations in the expression or function of PCDHgA2 can be associated with various neurological disorders, including autism spectrum disorders and schizophrenia. Given its significant role in neurobiology, there has been increasing interest in the study of recombinant PCDHgA2 proteins to better understand their structural properties, binding interactions, and functional mechanisms. Recombinant protein studies allow for the exploration of PCDHgA2's adhesive properties and its impact on neuron-neuron interactions, providing insights into the molecular basis of neural networks. Additionally, the purification and functional characterization of PCDHgA2 can pave the way for potential therapeutic strategies aimed at targeting protocols involved in neurodevelopmental disorders. Overall, the investigation of PCDHgA2 recombinant proteins promises to deepen our understanding of brain function and disease, highlighting its importance as a focal point in neurobiological research.
