Analytical Data
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Gene name
ICAM2
- Application
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Alternative Names
ICAM2;Intercellular adhesion molecule 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13598
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Expression Region
1-223aa
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AA Sequence
MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLAVEP KGSLEVNCST TCNQPEVGGL ETSLDKILLD EQAQWKHYLV SNISHDTVLQ CHFTCSGKQE SMNSNVSVYQ PPRQVILTLQ PTLVAVGKSF TIECRVPTVE PLDSLTLFLF RGNETLHYET FGKAAPAPQE ATATFNSTAD REDGHRNFSC LAVLDLMSRG GNIFHKHSAP KMLEIYEPVS DSQ
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Molecular Weight
50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ICAM-2 (Intercellular Adhesion Molecule-2) is a pivotal glycoprotein that plays a crucial role in the immune response by facilitating the adhesion of leukocytes to endothelial cells, thereby influencing inflammation and immune regulation. It belongs to the immunoglobulin superfamily and is primarily expressed on endothelial cells, where it interacts with lymphocyte function-associated antigen-1 (LFA-1), a vital receptor on T cells, facilitating their migration to sites of inflammation. Research on recombinant ICAM-2 proteins has gained significance in understanding the molecular mechanisms underlying immune cell trafficking and the pathogenesis of various inflammatory diseases. Moreover, studies involving the recombinant expression of ICAM-2 have shown potential applications in immunotherapy, where it could enhance the efficacy of vaccines or serve as a biomarker for certain diseases. With advances in molecular biology techniques, the ability to produce and characterize ICAM-2 as a recombinant protein has opened new avenues for therapeutic interventions, providing insights into its structure-function relationships and potential therapeutic roles in modulating immune responses. The ongoing research into ICAM-2 is not only essential for unraveling its biological functions but also for developing innovative strategies to target and treat inflammatory conditions and associated disorders.
