Analytical Data
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基因名
IQCC
- Application
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别名
IQCC; IQ domain-containing protein C
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q4KMZ1
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表达区间
1-466aa
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氨基酸序列
MEPELLVRKVSALQACVRGFLVRRQFQSLRAEYEAIVREVEGDLGTLQWTEGRIPRPRFLPEKAKSHQTWKAGDRVANPEQGLWNHFPCEESEGEATWEEMVLKKSGESSANQGSLCRDHSSWLQMKQNRKPSQEKTRDTTRMENPEATDQRLPHSQPQLQELQYHRSHLAMELLWLQQAINSRKEYLLLKQTLRSPEAGPIREEPRVFLEHGEQACERDQSQPSAPLEDQSYRDRTTGELEQEDDSCHRVKSPHRSPGSLATTQKNIAGAKCREPCYSKSGPPSSIPSNSQALGDRLTKGPDDGRQTFGGTCLLQMKILEDQTPRGLKPRNHCPRKSRTQLSALYEDSNIKEMSPRKLDHKEPDCRTVRTQELGLSEDHIIWDGTLGGPEHSVLDLWRTKPPKGQAPTDRSSRDGTSNEPSHEGQKKQRTIPWRSKSPEILSSTKAGCTGEEQWRGRPWKTEPPG
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分子量
79.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of IQCC (IscQ, IscS, and CcmE) recombinant proteins has emerged as a significant area of interest due to their pivotal role in the biogenesis of iron-sulfur (Fe-S) clusters, which are essential cofactors for a variety of enzymes involved in crucial metabolic processes. Fe-S clusters are vital for cellular respiration, DNA repair, and various redox reactions, and their dysfunction is linked to numerous diseases, including neurodegenerative disorders and cancer. Research into IQCC proteins has been driven by the need to understand the molecular mechanisms underlying Fe-S cluster assembly and the intricate interactions involved in this process. By expressing and purifying recombinant IQCC proteins, scientists can dissect their structural and functional properties, providing insights into their enzymatic activity and regulatory functions within cells. Furthermore, the study of these proteins has implications in biotechnology, where harnessing their assembly capabilities can lead to advancements in synthetic biology and bioengineering applications. Overall, IQCC recombinant protein research not only contributes to our fundamental understanding of cellular biochemistry but also opens avenues for innovative therapeutic strategies and industrial applications.
