Analytical Data
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Gene name
IPMK
- Application
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Alternative Names
3; 4; 6-tetrakisphosphate 5-kinase; Inositol 1; Inositol 1.3.4.6 tetrakisphosphate 5 kinase; Inositol polyphosphate multikinase; Ipmk; IPMK_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFU5
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Expression Region
1-416aa
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AA Sequence
MATEPPSPLRVEAPGPPEMRTSPAIESTPEGTPQPAGGRLRFLNGCVPLSHQVAGHMYGKDKVGILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSSQPTTTKLNDRTLAEKFLSKGQLSDTEVLEYNNNFHVLSSTANGKIESSVGKSLSKMYARHRKIYTKKHHSQTSLKVENLEQDNGWKSMSQEHLNGNVLSQLEKVFYHLPTGCQEIAEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN
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Molecular Weight
73.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IPMK (Inositol Polyphosphate Multikinase) is a multifunctional enzyme that plays a critical role in various cellular processes, including signal transduction, cell growth, and metabolism. Its ability to phosphorylate inositol polyphosphates influences numerous physiological functions and is vital for maintaining cellular homeostasis. Recent research has highlighted IPMK's involvement in diverse biological pathways, such as insulin signaling and gene expression regulation, linking it to metabolic disorders and specific cancers. Given the growing interest in understanding its functional mechanisms and regulatory roles, the recombinant expression of IPMK has become a focal point in molecular biology. Producing IPMK in a controlled environment permits detailed structural and functional studies, facilitating the identification of potential therapeutic targets. Additionally, the exploration of IPMK interactions with other signaling molecules can provide insights into its precise roles in cellular networks. Overall, the investigation of recombinant IPMK protein not only enhances our understanding of its biological significance but also paves the way for novel strategies in treating diseases associated with its dysfunction.
