Analytical Data
-
Gene name
INVS
- Application
-
Alternative Names
INVS; INV; NPHP2; Inversin; Inversion of embryo turning homolog; Nephrocystin-2
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9Y283
-
Expression Region
1-101aa
-
AA Sequence
MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKALRTISTGRI
-
Molecular Weight
36.85 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
INVS (inversin) is a protein encoded by the INVS gene, primarily known for its role in normal kidney development and function, as well as its implications in polycystic kidney disease (PKD). Dysregulation or mutations in the INVS gene lead to severe developmental abnormalities, including disorders such as nephronophthisis and Bardet-Biedl syndrome. Researchers have increasingly focused on INVS due to its involvement in the planar cell polarity (PCP) signaling pathway, which is crucial for cellular organization and tissue morphogenesis. The study of INVS and its recombinant proteins offers insights into the molecular mechanisms that underlie kidney organogenesis and the pathophysiology of cystic kidney diseases. By producing INVS as a recombinant protein, scientists can investigate its functional properties, interaction with other cellular components, and potential therapeutic interventions for PKD. Additionally, understanding the structure and dynamics of INVS can aid in the development of targeted treatments that influence its activity and mitigate disease progression, thereby enhancing our ability to address the challenges posed by congenital kidney disorders.
