Analytical Data
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基因名
KLC1
- Application
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别名
KLC1；KLC；KNS2；Kinesin light chain 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q07866
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表达区间
1-573aa
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氨基酸序列
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
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分子量
65.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLC1 (Kinesin Light Chain 1) is a crucial protein involved in intracellular transport, functioning as a key component of the kinesin motor protein complex. This complex is essential for the transport of various cellular cargoes, including organelles, protein complexes, and vesicles, along microtubules. Dysregulation or mutations in KLC1 are implicated in several neurodegenerative disorders, highlighting its significance in neuronal health and function. Research in KLC1 recombinant proteins has expanded due to the need to understand its structural properties and interactions with cargoes and other kinesin subunits. The production of recombinant KLC1 allows for in-depth biochemical and biophysical analyses, enabling researchers to investigate its role in cellular transport mechanisms. Furthermore, understanding KLC1's interactions within the kinesin complex can shed light on the molecular basis of transport-related diseases and potentially reveal novel therapeutic targets. Recent studies have focused on the elucidation of KLC1's binding motifs, its regulation by post-translational modifications, and its impact on cellular signaling pathways. This research contributes to a broader understanding of motor protein functionality and its implications in human health, as well as in the development of strategies to combat diseases linked to transport dysfunctions.
