Analytical Data
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Gene name
KLC1
- Application
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Alternative Names
KLC1；KLC；KNS2；Kinesin light chain 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q07866
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Expression Region
1-573aa
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AA Sequence
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
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Molecular Weight
65.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KLC1 (Kinesin Light Chain 1) is a crucial protein involved in intracellular transport, functioning as a key component of the kinesin motor protein complex. This complex is essential for the transport of various cellular cargoes, including organelles, protein complexes, and vesicles, along microtubules. Dysregulation or mutations in KLC1 are implicated in several neurodegenerative disorders, highlighting its significance in neuronal health and function. Research in KLC1 recombinant proteins has expanded due to the need to understand its structural properties and interactions with cargoes and other kinesin subunits. The production of recombinant KLC1 allows for in-depth biochemical and biophysical analyses, enabling researchers to investigate its role in cellular transport mechanisms. Furthermore, understanding KLC1's interactions within the kinesin complex can shed light on the molecular basis of transport-related diseases and potentially reveal novel therapeutic targets. Recent studies have focused on the elucidation of KLC1's binding motifs, its regulation by post-translational modifications, and its impact on cellular signaling pathways. This research contributes to a broader understanding of motor protein functionality and its implications in human health, as well as in the development of strategies to combat diseases linked to transport dysfunctions.
