Analytical Data
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基因名
ORP150
- Application
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别名
ORP150；GRP170；HSPH4；ORP150；Hypoxia up-regulated Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y4L1
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表达区间
695-994aa
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氨基酸序列
MVEEIGVELV VLDLPDLPED KLAQSVQKLQ DLTLRDLEKQ EREKAANSLE AFIFETQDKL YQPEYQEVST EEQREEISGK LSAASTWLED EGVGATTVML KEKLAELRKL CQGLFFRVEE RKKWPERLSA LDNLLNHSSM FLKGARLIPE MDQIFTEVEM TTLEKVINET WAWKNATLAE QAKLPATEKP VLLSKDIEAK MMALDREVQY LLNKAKFTKP RPRPKDKNGT RAEPPLNASA SDQGEKVIPP AGQTEDAEPI SEPEKVETGS EPGDTEPLEL GGPGAEPEQK EQSTGQKRPL
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ORP150 (Oxysterol-Binding Protein-Related Protein 150) is a member of the family of proteins involved in lipid metabolism and cellular stress responses. It functions primarily in the endoplasmic reticulum (ER) and plays a crucial role in maintaining cellular homeostasis by regulating the unfolded protein response (UPR) and aiding in protein folding and trafficking. Research into ORP150 has gained momentum due to its association with various diseases, including neurodegenerative disorders and cancers, where its expression levels are often altered. Studies have shown that ORP150 modulates inflammatory processes and contributes to cell survival under stress conditions, highlighting its potential as a therapeutic target. The reconstitution of ORP150 as a recombinant protein has facilitated the exploration of its biochemical properties, interactions with lipids, and signaling pathways, providing insights into its functional roles in health and disease. Overall, the investigation of ORP150 is pivotal for understanding the molecular mechanisms underlying ER stress and its implications in disease pathology, paving the way for novel therapeutic approaches.
