Analytical Data
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基因名
HSD17B8
- Application
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别名
CBR4;SDR45C1;3-oxoacyl-[acyl-carrier-Protein] reductase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92506
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表达区间
1-261aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M
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分子量
29 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSD17B8, or Hydroxysteroid 17-beta dehydrogenase 8, is a member of the 17β-hydroxysteroid dehydrogenase family, primarily involved in the oxidative and reductive conversion of steroid hormones. Research surrounding HSD17B8 has gained attention due to its potential implications in various physiological and pathological processes, including reproductive health, steroid metabolism, and cancer biology. Unlike other 17β-HSD isoforms, HSD17B8 is predominantly expressed in human testes, suggesting a vital role in male reproductive function. Furthermore, alterations in HSD17B8 activity have been linked to abnormal steroid concentrations that may influence sperm production, hormone regulation, and even fertility issues. Understanding the functional properties of HSD17B8 and its role in steroidogenesis can provide insights into developmental biology and the impact of hormonal imbalances. The production of recombinant HSD17B8 protein has facilitated detailed biochemical studies, allowing researchers to explore its enzymatic activity, regulatory mechanisms, and potential as a therapeutic target in conditions related to steroid hormone dysregulation. Investigating the structure and function of HSD17B8 not only enhances our comprehension of steroid metabolism but also opens avenues for developing targeted therapies in hormone-related diseases, making this protein a significant focus of research in endocrinology and reproductive biology.
