Analytical Data
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基因名
COL9a3
- Application
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别名
COL9a3；Collagen alpha-3(IX) chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14050
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表达区间
26-684aa
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氨基酸序列
QRVGL PGPPGPPGPP GKPGQDGIDG EAGPPGLPGP PGPKGAPGKP GKPGEAGLPG LPGVDGLTGR DGPPGPKGAP GERGSLGPPG PPGLGGKGLP GPPGEAGVSG PPGGIGLRGP PGPSGLPGLP GPPGPPGPPG HPGVLPEGAT DLQCPSICPP GPPGPPGMPG FKGPTGYKGE QGEVGKDGEK GDPGPPGPAG LPGSVGLQGP RGLRGLPGPL GPPGDRGPIG FRGPPGIPGA PGKAGDRGER GPEGFRGPKG DLGRPGPKGT PGVAGPSGEP GMPGKDGQNG VPGLDGQKGE AGRNGAPGEK GPNGLPGLPG RAGSKGEKGE RGRAGELGEA GPSGEPGVPG DAGMPGERGE AGHRGSAGAL GPQGPPGAPG VRGFQGQKGS MGDPGLPGPQ GLRGDVGDRG PGGAAGPKGD QGIAGSDGLP GDKGELGPSG LVGPKGESGS RGELGPKGTQ GPNGTSGVQG VPGPPGPLGL QGVPGVPGIT GKPGVPGKEA SEQRIRELCG GMISEQIAQL AAHLRKPLAP GSIGRPGPAG PPGPPGPPGS IGHPGARGPP GYRGPTGELG DPGPRGNQGD RGDKGAAGAG LDGPEGDQGP QGPQGVPGTS KDGQDGAPGE PGPPGDPGLP GAIGAQGTPG ICDTSACQGA VLGGVGEKSG SRSS
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分子量
63.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL9A3, a member of the collagen family, encodes the alpha-3 chain of type IX collagen, which is a crucial component of the extracellular matrix in various tissues, particularly in cartilage. It plays a significant role in maintaining the structural integrity and functionality of cartilage, making it vital for joint health. Mutations in the COL9A3 gene have been linked to several musculoskeletal disorders, including osteoarthritis and idiopathic skeletal dysplasia, highlighting its importance in pathophysiology. The production of recombinant COL9A3 protein facilitates the investigation of its structural properties and biological functions, enabling researchers to understand its role in cartilage development and disease. Additionally, COL9A3's interactions with other matrix components are critical for the organization of the collagen network, impacting tissue mechanics. Consequently, studying this protein provides insights into therapeutic targets for cartilage-related diseases and the potential for developing regenerative medicine applications. Understanding the nuances of COL9A3 in both healthy and diseased states is essential for advancing strategies aimed at improving joint health and treating degenerative conditions. As research progresses, the recombinant form of COL9A3 could serve as a valuable tool in both basic research and clinical applications, bridging gaps in knowledge regarding cartilage biology and disease mechanisms.
