Analytical Data
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基因名
HPGDS
- Application
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别名
HPGDS;GSTS;PGDS;PTGDS2;Hematopoietic prostaglandin D synthase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60760
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表达区间
1-199aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMPNYKL TYFNMRGRAE IIRYIFAYLD IQYEDHRIEQ ADWPEIKSTL PFGKIPILEV DGLTLHQSLA IARYLTKNTD LAGNTEMEQC HVDAIVDTLD DFMSCFPWAE KKQDVKEQMF NELLTYNAPH LMQDLDTYLG GREWLIGNSV TWADFYWEIC STTLLVFKPD LLDNHPRLVT LRKKVQAIPA VANWIKRRPQ TKL
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HPGDS (Hematopoietic Prostaglandin D Synthase) is an enzyme involved in the biosynthesis of prostaglandin D2 (PGD2), a crucial mediator in various physiological and pathological processes, including sleep regulation, immune response, and inflammatory diseases. Previous studies have highlighted the significance of PGD2 in modulating the function of certain immune cells, as well as its role in neuroprotection and allergic responses. Due to its involvement in significant biological pathways, HPGDS has emerged as a potential therapeutic target for conditions like asthma, sleep disorders, and even neurodegenerative diseases. The study of recombinant HPGDS protein allows for detailed investigations into its structure, enzymatic mechanisms, and interaction with substrates and inhibitors. By producing HPGDS through recombinant techniques, researchers can obtain the protein in a pure and abundant form, facilitating studies that explore its functional properties and provide insights into drug design. Understanding the regulation and functionality of HPGDS can lead to the development of novel therapeutic interventions aimed at modulating PGD2 levels, thereby offering new avenues for treating diseases associated with dysregulated prostaglandin signaling.
