Analytical Data
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Gene name
MATN1
- Application
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Alternative Names
MATN1；CMP；CRTM；Cartilage matrix Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21941
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Expression Region
23-496aa
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AA Sequence
SPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV
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Molecular Weight
57.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MATN1, or Matrilin-1, is a non-collagenous extracellular matrix protein that plays a critical role in the structural integrity and function of various connective tissues. It is predominantly expressed in cartilage, tendons, and ligaments, where it interacts with other matrix components, facilitating the assembly of extracellular matrix networks. Research has shown that MATN1 is involved in cellular processes such as proliferation, migration, and differentiation, making it a significant factor in tissue development and repair. Abnormal expression of MATN1 has been implicated in several pathologies, including osteoarthritis, where it may contribute to cartilage degradation and altered biomechanical properties. The study of MATN1 recombinant proteins has gained attention as a means to understand its functional roles and interactions within the extracellular matrix, which could have implications for developing therapeutic strategies for connective tissue disorders. Recombinant MATN1 proteins are being used in various experimental models to elucidate their biological effects and potential as biomarkers or therapeutic agents. This focus on MATN1 reaffirms the importance of extracellular matrix components in health and disease, highlighting the need for continued research in elucidating the molecular mechanisms governing connective tissue homeostasis and pathological conditions affecting these crucial structures.
