Analytical Data
-
Gene name
IKBKG
- Application
-
Alternative Names
IKBKG. FIP3. NEMO
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9Y6K9
-
Expression Region
1-419aa
-
AA Sequence
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
-
Molecular Weight
71.83 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IKBKG, also known as IκB kinase gamma, is a crucial component of the NF-κB signaling pathway, playing a significant role in immune response, inflammation, and cell survival. Research into IKBKG is particularly vital due to its involvement in various diseases, including autoimmune disorders, cancers, and inflammatory diseases. Mutations in the IKBKG gene can lead to immunodeficiency syndromes, underscoring its importance in maintaining immune homeostasis. As scientists seek to understand the intricate mechanisms of NF-κB regulation, the recombinant IKBKG protein is essential for elucidating its structure-function relationships, assessing its interactions with upstream and downstream signaling molecules, and investigating its role in disease pathology. Furthermore, the production of IKBKG as a recombinant protein enables the development of therapeutic strategies that could target NF-κB signaling, offering potential treatments for diseases characterized by dysregulated inflammation and immune responses. The exploration of IKBKG's function at the molecular level is not only critical for advancing our understanding of immune system dynamics but also holds promise for innovative approaches in clinical therapy.
