Analytical Data
-
Gene name
HOMER2
- Application
-
Alternative Names
HOMER2;Homer Protein homolog 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9NSB8
-
Expression Region
1-354aa
-
AA Sequence
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
-
Molecular Weight
48.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HOMER2 is a member of the Homer family of proteins, which are crucial for synaptic signaling and the organization of neuronal networks. As an essential scaffolding protein, HOMER2 interacts with various receptors, including metabotropic glutamate receptors (mGluRs) and inositol trisphosphate receptors (IP3Rs), playing a pivotal role in signal transduction pathways involved in synaptic plasticity and neurodevelopment. Research has indicated that HOMER2 is implicated in various neurological conditions, including schizophrenia, autism, and substance abuse disorders, highlighting its importance in maintaining synaptic integrity and function. The study of HOMER2 recombinant proteins provides valuable insights into its structure-function relationships, enabling researchers to dissect its specific interactions and regulatory mechanisms. Advances in recombinant protein technology have made it possible to produce HOMER2 in sufficient quantities for biochemical assays and structural analyses. Understanding the precise role of HOMER2 in neuronal signaling not only contributes to basic neuroscience but also has potential therapeutic implications for targeted treatments in synaptopathies and related disorders. As investigations into HOMER2 continue to evolve, the knowledge gained from these studies may pave the way for innovative strategies aimed at modulating synaptic functions in various brain disorders.
