Analytical Data
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基因名
HNRNPAB
- Application
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别名
HNRNPAB;ABBP1;HNRPAB;Heterogeneous nuclear ribonucleoProtein A/B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99729
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表达区间
1-332aa
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氨基酸序列
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HNRNPAB, or heterogeneous nuclear ribonucleoprotein A/B, is an essential protein involved in the regulation of RNA processing, splicing, and transport within the cell nucleus. It plays a crucial role in the post-transcriptional regulation of gene expression, influencing processes such as mRNA stability and localization. Research into HNRNPAB has gained attention due to its implications in various biological processes and diseases, including cancer and neurodegeneration. Abnormal expression levels of HNRNPAB have been linked to the dysregulation of alternative splicing events, which can lead to the production of oncogenic isoforms and contribute to tumor progression. Furthermore, its interactions with other RNA-binding proteins and non-coding RNAs enhance its functional complexity, making it a critical player in the intricate network of gene regulation. The generation of recombinant HNRNPAB protein is essential for studying its biochemical properties and functional interactions, allowing researchers to elucidate its role in cellular processes and its potential as a therapeutic target. Understanding the structure and function of HNRNPAB can provide insights into its mechanistic role in health and disease, paving the way for the development of novel strategies in cancer treatment and other disorders associated with RNA processing defects. Therefore, research on HNRNPAB and its recombinant forms represents a promising frontier in molecular biology, with significant implications for understanding the underlying mechanisms of gene regulation and the pathogenesis of various diseases.
