Analytical Data
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Gene name
HNRNPAB
- Application
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Alternative Names
HNRNPAB;ABBP1;HNRPAB;Heterogeneous nuclear ribonucleoProtein A/B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99729
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Expression Region
1-332aa
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AA Sequence
MSEAGEEQPM ETTGATENGH EAVPEASRGR GWTGAAAGAG GATAAPPSGN QNGAEGDQIN ASKNEEDAGK MFVGGLSWDT SKKDLKDYFT KFGEVVDCTI KMDPNTGRSR GFGFILFKDA ASVEKVLDQK EHRLDGRVID PKKAMAMKKD PVKKIFVGGL NPESPTEEKI REYFGEFGEI EAIELPMDPK LNKRRGFVFI TFKEEEPVKK VLEKKFHTVS GSKCEIKVAQ PKEVYQQQQY GSGGRGNRNR GNRGSGGGGG GGGQSQSWNQ GYGNYWNQGY GYQQGYGPGY GGYDYSPYGY YGYGPGYDYS QGSTNYGKSQ RRGGHQNNYK PY
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HNRNPAB, or heterogeneous nuclear ribonucleoprotein A/B, is an essential protein involved in the regulation of RNA processing, splicing, and transport within the cell nucleus. It plays a crucial role in the post-transcriptional regulation of gene expression, influencing processes such as mRNA stability and localization. Research into HNRNPAB has gained attention due to its implications in various biological processes and diseases, including cancer and neurodegeneration. Abnormal expression levels of HNRNPAB have been linked to the dysregulation of alternative splicing events, which can lead to the production of oncogenic isoforms and contribute to tumor progression. Furthermore, its interactions with other RNA-binding proteins and non-coding RNAs enhance its functional complexity, making it a critical player in the intricate network of gene regulation. The generation of recombinant HNRNPAB protein is essential for studying its biochemical properties and functional interactions, allowing researchers to elucidate its role in cellular processes and its potential as a therapeutic target. Understanding the structure and function of HNRNPAB can provide insights into its mechanistic role in health and disease, paving the way for the development of novel strategies in cancer treatment and other disorders associated with RNA processing defects. Therefore, research on HNRNPAB and its recombinant forms represents a promising frontier in molecular biology, with significant implications for understanding the underlying mechanisms of gene regulation and the pathogenesis of various diseases.
