Analytical Data
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Gene name
HMGN3
- Application
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Alternative Names
HMGN3;TRIP7;High mobility group nucleosome-binding domain-containing Protein 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15651-2
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Expression Region
1-77aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN
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Molecular Weight
11 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HMGN3 (High Mobility Group Nucleosome-Binding protein 3) is a member of the HMGN protein family, which plays an essential role in chromatin structure and gene regulation. These proteins are non-histone chromatin-binding factors that interact directly with nucleosomes, influencing their positioning and stabilizing the chromatin structure. Research on HMGN3 has gained considerable attention due to its potential implications in various biological processes, including transcriptional regulation, DNA damage response, and cellular differentiation. Studies have shown that HMGN3 can modulate the activity of chromatin remodeling complexes and is involved in enhancing or repressing the transcription of specific genes. Furthermore, alterations in HMGN3 expression levels have been associated with several diseases, including cancer and neurodegenerative disorders, making it a subject of interest for therapeutic interventions. The recombinant production of HMGN3 protein allows for in-depth functional studies and provides insights into its mechanism of action within the chromatin landscape. By understanding how HMGN3 interacts with other chromatin components and regulatory factors, researchers aim to elucidate its role in gene expression regulation and its potential as a biomarker or therapeutic target in disease contexts. Ongoing investigations into the structural and functional characteristics of recombinant HMGN3 could pave the way for novel strategies in biotechnology and medicine, highlighting the importance of this protein in the broader context of chromatin biology.
