Analytical Data
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Gene name
BACE2
- Application
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Alternative Names
BACE2；AEPLC；ALP56；ASP21；Beta-secretase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5Z0
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Expression Region
1-518aa
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AA Sequence
MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
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Molecular Weight
56.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BACE2, or Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2, is a crucial enzyme involved in the processing of amyloid precursor proteins, which play a significant role in the pathogenesis of Alzheimer's disease. Research into BACE2 has gained traction due to its potential role in regulating amyloid-beta peptide levels, a hallmark of Alzheimer's pathology. Unlike its homolog BACE1, which is heavily implicated in disease progression, BACE2 appears to have a protective effect, as it may cleave amyloid precursor proteins in a manner that reduces toxic amyloid-beta accumulation. Understanding the functional mechanisms and structural characteristics of BACE2 through the study of its recombinant protein is essential for elucidating its therapeutic potential. Recombinant BACE2 protein enables researchers to explore its enzymatic activity, interaction with substrates, and regulation by other molecular factors, thus opening avenues for the development of novel therapeutic approaches aimed at modulating its activity. Additionally, insights gained from such studies could inform drug discovery efforts targeting Alzheimer's disease and related neurodegenerative conditions. As a result, the investigation of BACE2 recombinant protein not only enhances our understanding of amyloid processing but also provides a promising platform for the design of innovative strategies to combat Alzheimer's disease.
