Analytical Data
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Gene name
IBRDC1
- Application
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Alternative Names
RNF217; C6orf172; IBRDC1; OSTL; E3 ubiquitin-protein ligase RNF217; IBR domain-containing protein 1; Opposite STL; RING finger protein 217
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TC41
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Expression Region
2-100aa
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AA Sequence
KVQLGQVEIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHE
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Molecular Weight
36.63 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IBRDC1, or Iron-Binding Regulator of Dicer 1, is a protein that plays a crucial role in the regulation of microRNA biogenesis and iron metabolism. Its discovery stems from the need to understand the intricate mechanisms of RNA processing and the impact of iron homeostasis on cellular functions. Recent studies have indicated that IBRDC1 is involved in modulating the activity of Dicer, an essential enzyme that processes precursor microRNAs into their functional form, thus influencing gene expression and various cellular pathways. Dysregulation of IBRDC1 has been linked to various diseases, including cancer and neurodegenerative disorders. Investigating IBRDC1's structure and function can provide insights into its role in cellular iron regulation and RNA processing, potentially opening new avenues for therapeutic strategies targeting iron-related diseases and disorders of gene expression. The research into IBRDC1 and its recombinant protein form aims to elucidate its mechanism of action, interactions with other cellular components, and its overall contribution to maintaining cellular homeostasis, making it a significant focus in molecular and cellular biology.











