Analytical Data
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Gene name
CK10
- Application
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Alternative Names
CK10；C11orf10；Transmembrane Protein 258
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13645
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Expression Region
345-454aa
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AA Sequence
KELTTEIDNNIEQISSYKSEITELRRNVQALEIELQSQLALKQSLEASLA ETEGRYCVQLSQIQAQISALEEQLQ QIRAETECQNTEYQQLLDIKIRL ENEIQTYRSLLE
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Molecular Weight
38 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK10, or Cytokeratin 10, is a crucial intermediate filament protein predominantly expressed in the epidermis and certain external epithelial tissues, playing a vital role in maintaining the structural integrity and functional properties of keratinocytes. Research on CK10 recombinant protein has gained prominence due to its significant involvement in skin health, wound healing, and various dermatological conditions. Alterations in CK10 expression are often linked to skin disorders such as psoriasis, eczema, and skin cancers, underscoring its potential as a biomarker for disease progression and therapeutic target. Recombinant CK10 is used in various studies to elucidate the mechanisms of keratinocyte differentiation and to explore its interactions with other cellular components. Moreover, the production of CK10 as a recombinant protein enables researchers to investigate its functional properties in vitro and in vivo, paving the way for novel therapeutic strategies aimed at enhancing skin regeneration and treating skin-related diseases. Understanding the biochemical properties and regulatory mechanisms of CK10 can significantly contribute to the fields of dermatology and regenerative medicine, making it a focal point of interest for scientists seeking to discover innovative approaches to enhance skin health and address various skin pathologies. Therefore, the investigation of CK10 recombinant protein not only adds to the basic understanding of epidermal biology but also holds the promise of leading to practical applications in clinical treatments for skin disorders.
