Analytical Data
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Gene name
HEXIM1
- Application
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Alternative Names
HEXIM1;CLP1;EDG1;HIS1;Protein HEXIM1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94992
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Expression Region
1-359aa
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AA Sequence
MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSR AFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAG GDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGK KKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPV APYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDG GSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSR MEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQE RAPLSKFGD
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Molecular Weight
65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HEXIM1 (Hexamethylenebisacetamide-Inducible Protein 1) is a critical regulator of gene expression, primarily known for its role in the control of transcription mediated by the positive transcription elongation factor b (P-TEFb). Recent studies have highlighted the importance of HEXIM1 in various cellular processes, including differentiation, proliferation, and response to stress signals. Originally identified as a protein that can inhibit P-TEFb, HEXIM1's function extends to modulating RNA polymerase II activity and influencing the expression of several genes, including those involved in viral infections and cancer. Given its diverse roles, HEXIM1 has garnered attention as a potential therapeutic target. Research into its recombinant protein form aims to elucidate its structure-function relationship and regulatory mechanisms. By producing HEXIM1 as a recombinant protein, scientists can investigate its interactions with other proteins, analyze its role in transcriptional regulation, and explore its potential in clinical applications, such as antiviral therapies and cancer treatment. Understanding the biochemical properties of HEXIM1 may provide insights into the dysregulation of transcriptional processes observed in various diseases, paving the way for the development of novel therapeutic strategies.
