Analytical Data
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基因名
SGMS1
- Application
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别名
SGMS1；KIAA0397；RUTBC1；Small G Protein signaling modulator 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86VZ5
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表达区间
1-413aa
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氨基酸序列
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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分子量
48.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of SGMS1, or Sphingomyelin Synthase 1, has gained significant attention due to its pivotal role in sphingolipid metabolism and cellular signaling. Sphingolipids, including sphingomyelin, are essential components of cell membranes and play crucial roles in various cellular processes, including proliferation, differentiation, and apoptosis. Abnormalities in sphingolipid pathways have been linked to numerous diseases, including cancer, neurodegenerative disorders, and metabolic diseases. SGMS1 specifically catalyzes the synthesis of sphingomyelin from ceramide, thus influencing membrane integrity and function. Recent research has indicated that altered SGMS1 expression and activity can impact the development and progression of these diseases, underscoring its potential as a therapeutic target. Recombinant SGMS1 protein has been produced to further elucidate its biochemical properties, functional roles, and regulatory mechanisms within sphingolipid metabolism. By using this recombinant protein, scientists aim to explore its interactions with other cellular components and to assess its enzymatic activity under different physiological and pathological conditions. Understanding SGMS1's structure and function can provide deeper insights into sphingolipid biology, potentially leading to the development of novel therapeutic strategies for diseases associated with sphingolipid dysregulation.
