Analytical Data
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Gene name
SGMS1
- Application
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Alternative Names
SGMS1；KIAA0397；RUTBC1；Small G Protein signaling modulator 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VZ5
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Expression Region
1-413aa
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AA Sequence
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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Molecular Weight
48.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of SGMS1, or Sphingomyelin Synthase 1, has gained significant attention due to its pivotal role in sphingolipid metabolism and cellular signaling. Sphingolipids, including sphingomyelin, are essential components of cell membranes and play crucial roles in various cellular processes, including proliferation, differentiation, and apoptosis. Abnormalities in sphingolipid pathways have been linked to numerous diseases, including cancer, neurodegenerative disorders, and metabolic diseases. SGMS1 specifically catalyzes the synthesis of sphingomyelin from ceramide, thus influencing membrane integrity and function. Recent research has indicated that altered SGMS1 expression and activity can impact the development and progression of these diseases, underscoring its potential as a therapeutic target. Recombinant SGMS1 protein has been produced to further elucidate its biochemical properties, functional roles, and regulatory mechanisms within sphingolipid metabolism. By using this recombinant protein, scientists aim to explore its interactions with other cellular components and to assess its enzymatic activity under different physiological and pathological conditions. Understanding SGMS1's structure and function can provide deeper insights into sphingolipid biology, potentially leading to the development of novel therapeutic strategies for diseases associated with sphingolipid dysregulation.
