Analytical Data
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Gene name
HAT1
- Application
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Alternative Names
HAT1;KAT1;Histone acetyltransferase type B catalytic subunit
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14929
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Expression Region
2-419aa
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AA Sequence
AGFGAMEKF LVEYKSAVEK KLAEYKCNTN TAIELKLVRF PEDLENDIRT FFPEYTHQLF GDDETAFGYK GLKILLYYIA GSLSTMFRVE YASKVDENFD CVEADDVEGK IRQIIPPGFC TNTNDFLSLL EKEVDFKPFG TLLHTYSVLS PTGGENFTFQ IYKADMTCRG FREYHERLQT FLMWFIETAS FIDVDDERWH YFLVFEKYNK DGATLFATVG YMTVYNYYVY PDKTRPRVSQ MLILTPFQGQ GHGAQLLETV HRYYTEFPTV LDITAEDPSK SYVKLRDFVL VKLCQDLPCF SREKLMQGFN EDMAIEAQQK FKINKQHARR VYEILRLLVT DMSDAEQYRS YRLDIKRRLI SPYKKKQRDL AKMRKCLRPE ELTNQMNQIE ISMQHEQLEE SFQELVEDYR RVIERLAQE
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HAT1 (Histone Acetyltransferase 1) is a critical enzyme involved in the acetylation of histone proteins, which plays a significant role in the regulation of gene expression and chromatin dynamics. The study of HAT1 has gained considerable attention due to its implications in various biological processes, including cell differentiation, proliferation, and the response to DNA damage. Dysregulation of HAT1 activity has been associated with several pathological conditions, such as cancer and other diseases linked to epigenetic alterations. Research on recombinant HAT1 protein aims to elucidate its structural and functional characteristics, providing insights into its mechanism of action and interactions with other cellular components. Additionally, generating recombinant HAT1 allows for the assessment of its specific role in histone modification and chromatin remodeling. By employing advanced biophysical and biochemical techniques, scientists aim to explore how HAT1 influences chromatin architecture and gene expression patterns, which could lead to the development of novel therapeutic strategies targeting epigenetic regulators. Understanding HAT1's function in normal and disease contexts is crucial for advancing our knowledge of epigenetic control and its potential as a therapeutic target.
