Analytical Data
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Gene name
HAO1
- Application
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Alternative Names
HAO1;GOX1;2-Hydroxyacid oxidase 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJM8
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Expression Region
1-370aa
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AA Sequence
MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMLPRLICINDYEQH AKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLST SVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSS IEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYL GNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAID PSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQ LDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVG RPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNP LAVSKI
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HAO1, or HAO1 protein, plays a crucial role in cellular metabolism and has garnered significant interest in recent years due to its involvement in various physiological processes. This protein is an enzyme that participates in the oxidative stress response by catalyzing the conversion of hydroxylamines to aldehydes, thus mitigating the potential damage caused by reactive oxygen species (ROS). Research has shown that dysregulation of HAO1 expression is linked to several pathological conditions, including neurodegenerative diseases and cancer. The study of HAO1 recombinant protein is vital for understanding its structure-function relationships, enzymatic mechanisms, and interactions with other cellular components. Moreover, the ability to produce HAO1 in a recombinant form allows for detailed biochemical characterization and the exploration of its therapeutic potential. As researchers continue to elucidate the biological significance of HAO1, the insights gained may pave the way for targeted interventions in diseases associated with oxidative stress and cellular dysfunction. Understanding HAO1's role at a molecular level may also contribute to the development of novel diagnostic and therapeutic approaches aimed at enhancing cellular resilience against oxidative damage. This increasing body of knowledge positions HAO1 at the forefront of metabolic research, underscoring its importance in both basic biology and clinical applications.
