Analytical Data
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基因名
HSD17B7
- Application
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别名
HSD17B7; 17HSD7; SDR37C1; UNQ2563/PRO6243; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; 3-keto-steroid reductase; Dihydrotestosterone oxidoreductase
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56937
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表达区间
1-341aa
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氨基酸序列
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
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分子量
64.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSD17B7, or hydroxysteroid 17-beta dehydrogenase 7, is an important enzyme involved in the biosynthesis of steroid hormones and cholesterol. Its primary function is to facilitate the conversion of ionone derivatives to their corresponding alcohols, which is crucial in the metabolic pathways of sex steroids and other physiological processes. The study of HSD17B7 has gained significant attention in the fields of endocrinology and biochemistry due to its potential implications in various diseases, including metabolic disorders, reproductive health issues, and certain cancers. Recombinant protein technology has emerged as an essential tool to investigate the structure and function of HSD17B7. By expressing the enzyme in host systems such as bacteria or yeast, researchers can obtain purified protein for functional studies, crystallization, and structural analyses. Understanding the activity and regulation of HSD17B7 through these recombinant studies may provide insights into its role in disease mechanisms and identify potential therapeutic targets. Furthermore, the development of HSD17B7 inhibitors may open new avenues for treating hormone-related conditions. Thus, research on recombinant HSD17B7 not only enhances our understanding of steroid metabolism but also offers promising prospects for clinical applications in managing related health issues.
