Analytical Data
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基因名
GSDMB
- Application
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别名
GSDMB；GSDML；Gasdermin-B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAX9
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表达区间
1-411aa
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氨基酸序列
MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHYTTGLTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQYKFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDELASSPPDMDYDPEARILCALYVVVSILLELAEGPTSVSS
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分子量
54.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GSDMB (Gasdermin B) is a member of the gasdermin family of proteins, which play crucial roles in the regulation of inflammatory responses and pyroptosis, a form of programmed cell death associated with inflammation. Recent studies have highlighted GSDMB's potential contributions to various diseases, including cancer and autoimmune disorders, making it a significant focus of research in molecular biology and immunology. The interest in recombinant GSDMB protein stems from its intriguing functional properties and its ability to form pores in cellular membranes, which can lead to cell lysis and the release of pro-inflammatory cytokines. This research avenue aims to elucidate the precise mechanisms by which GSDMB exerts its effects on cellular homeostasis and immunity. By producing and characterizing recombinant GSDMB, scientists can dissect its interactions with other cellular components, identify potential post-translational modifications, and explore its role in disease pathogenesis. Understanding the structure-function relationship of GSDMB will not only enhance our knowledge of its biological roles but also create potential therapeutic opportunities for manipulating its activity in various pathological conditions. Overall, the study of recombinant GSDMB protein is poised to provide valuable insights into the intricate interplay between cellular signaling, inflammation, and cell death, highlighting its significance as a target for future therapeutic interventions.
