Analytical Data
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Gene name
GGA3
- Application
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Alternative Names
GGA3；KIAA0154；ADP-ribosylation factor-binding Protein GGA3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZ52
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Expression Region
1-690aa
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AA Sequence
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLKPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
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Molecular Weight
81.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GGA3 (Golgi-localized, gamma-ear-containing, ARF-binding protein 3) is a member of the GGA (Golgi-localized, γ-ear-containing, ARF-binding) family of proteins, which play crucial roles in the vesicular transport within the Golgi apparatus and endosomal system. Research into GGA3 has gained momentum due to its involvement in various cellular processes, including protein sorting, trafficking, and the modulation of signaling pathways. Dysregulation of GGA3 has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Additionally, GGA3 interacts with various cargo proteins and is essential for the proper functioning of the ubiquitin-proteasome system, which maintains cellular homeostasis. The functional characterization of GGA3, particularly through the study of recombinant protein, allows for a better understanding of its structural properties and mechanisms of action. Scientists aim to elucidate how GGA3 contributes to cellular dynamics, and its role in disease mechanisms, paving the way for the development of targeted therapies. With advances in protein expression and purification techniques, GGA3 recombinant protein studies have become vital for exploring its potential as a biomarker and its utility in drug discovery. Understanding the biophysical and biochemical properties of GGA3 in detail could provide insights into the broader implications of this protein in cellular functions and its relevance in pathology.
