Analytical Data
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基因名
CRLF3
- Application
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别名
CRLF3；CREME9；CRLM9；CYTOR4；Cytokine receptor-like factor 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IUI8
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表达区间
1-442aa
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氨基酸序列
MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQ TRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIE HGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLV DVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWC KVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVC ARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSES SGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQ AVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHF KLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF
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分子量
49.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRLF3 (Cytokine Receptor-Like Factor 3) is a relatively novel member of the cytokine receptor family, which plays a crucial role in various biological processes, including immune response and hematopoiesis. Its discovery arose from the need to better understand the regulatory mechanisms of cytokine signaling, as dysregulation in these pathways is often linked to numerous diseases, including cancers and autoimmune disorders. Researchers have identified CRLF3 as being involved in the modulation of signaling pathways that govern cell growth and differentiation. Initial studies suggested that CRLF3 might interact with various cytokines and their receptors, influencing cellular responses to inflammatory stimuli. Furthermore, the potential role of CRLF3 in the development of hematopoietic cells has spurred investigations into its expression patterns in different tissues and during various developmental stages. Notably, the reconstitution of CRLF3 as a recombinant protein has enabled scientists to explore its functional properties in vitro and in vivo models, providing insights into its receptor interactions and downstream signaling effects. This research could unveil novel therapeutic targets for diseases where cytokine signaling is perturbed, highlighting the importance of CRLF3 in both basic and clinical biomedical research. The ongoing studies aim to delineate the precise biological functions of CRLF3 and its implications in health and disease, thereby contributing to a more comprehensive understanding of the cytokine network.
